By Masayasu Hiraoka, International Congress on Electrocardiol
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Extra resources for Advances in Electrocardiology 2004: Proceedings of the 31th International Congress on Electrocardiology (Advances in Electrocardiography)
Studies by the group of Nattel have shown clearly that down regulation of the Ica-L is the main determinant of electrical remodeling. Brundel in our lab has shown a clear correlation between the atrial effective refractory period and L-type calcium channel protein expression. In addition, she showed that down regulation of the channel together with shortening of the atrial refractory period was most marked in patients with chronic atrial fibrillation. Experimental and clinical studies have shown that the action potential shortening and shortening of the refractory period is not enough to develop persistent atrial fibrillation.
KVLQT1, HERG, SCNSA, KCNE1, and KCNE2. Circulation 2000;102:1178-1185. 26. Moss AJ, Zareba W, Kaufman ES, et al: Increased risk of arrhythmic events in long-QT syndrome with mutations in the pore region of the human ether-a-go-go-related gene potassium channel. Circulation 2002; 105:794-799. 27. Schwartz PJ, Priori SG, Spazzolini C, et al: Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias. Circulation 200 1;103:89-95. 28. Priori SG, Napolitano C, Schwartz PJ, et al: Association of long QT syndrome loci and cardiac events among patients treated with beta-blockers.
12. Schwartz PJ, Malliani A: Electrical alternation of the T-wave: clinical and experimental evidence of its relationship with the sympathetic nervous system and with the long Q-T syndrome. Am Heart J 1975;89:45-50. 13. Moss AJ, McDonald J: Unilateral cervicothoracic sympathetic ganglionectomy for the treatment of long QT interval syndrome. N Engl J Med 1971;285:903-904. 14. Schwartz PJ, Periti M, Malliani A: The long Q-T syndrome. Am Heart J 1975;89:378-90. 15. Moss AJ, Schwartz PJ: Sudden death and the idiopathic long Q-T syndrome.