Advances in Nuclear Oncology: Diagnosis and Therapy by Emilio Bombardieri, John Buscombe, Giovanni Lucignani, Otmar

By Emilio Bombardieri, John Buscombe, Giovanni Lucignani, Otmar Schober

Nuclear imaging is more and more required to enquire advanced medical difficulties and to lead healing intervention. the main familiar nuclear agent is FDG, and whilst FDG puppy is mixed with CT, the nuclear medication healthcare professional and oncologist own the most important device certainly. the head caliber photos which are bought express beautiful anatomical and morphological element. Advances in Oncologic drugs offers the reader with crucial historical past details and a wealth of illustrative fabric to make sure quick illness development acceptance.

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11. Dowell J, Minna JD, Kirkpatrick P. Erlotinib hydrochloride. Nat Rev Drug Discov 2005; 4: 13–14. 12. Kane RC, Bross PF, Farrell AT, Pazdur R. Velcade: US FDA approval for the treatment of multiple myeloma progressing on prior therapy. Oncologist 2003; 8: 508–13. 13. Cunningham D, Humblet Y, Siena S et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecanrefractory metastatic colorectal cancer. N Engl J Med 2004; 351: 337–45. 14. Cohen MH, Johnson JR, Li N, Chen G, Pazdur R. Approval summary: letrozole in the treatment of postmenopausal women with advanced breast cancer.

Generally speaking, among the huge spectrum of targets being evaluated for preclinical purposes using different imaging modalities such as scintigraphy and fluorescence imaging, there are only a few molecular imaging targets which have been validated and established for clinical applications, in the vast majority using scintigraphic approaches such as positron emission tomography (PET) and single photon emission computed tomography (SPECT). 6 A review of new molecular imaging tracers for diagnostic purposes is additionally given in Chapter 31.

Lahorte CM, Vanderheyden JL, Steinmetz N et al. Apoptosisdetecting radioligands: current state of the art and future perspectives. Eur J Nucl Med Mol Imaging 2004; 31: 887–919. Reed JC, Pellecchia M. Apoptosis-based therapies for hematologic malignancies. Blood 2005; 106: 408–18. Rasey JS, Hofstrand PD, Chin LK, Tewson TJ. Characterization of [18F]fluoroetanidazole, a new radiopharmaceutical for detecting tumor hypoxia. J Nucl Med 1999; 40: 1072–9. g. utilization of glucose and other substrates, protein synthesis, and expression of receptors and antigens.

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