Anabolic Steroids by H.-L. Krüskemper (Auth.)

By H.-L. Krüskemper (Auth.)

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O n the o t h e r hand, the sparse d e v e l o p m e n t of m u s c u l a t u r e in e u n u c h s has b e e n k n o w n since antiquity. In a m o r e r e c e n t series of investigations, it w a s found that in only 1 6 % of 150 e u n u c h s , c o m p a r e d to normal males of the s a m e age g r o u p , w a s the skeletal m u s c u l a t u r e developed to the s a m e extent as in t h e s e normal males (196). T h e suspected d e p e n d e n c e on a n d r o g e n s of muscle d e v e l o p m e n t w a s d e m o n s t r a t e d in animal e x p e r i m e n t s ; in male guinea pigs t h e t e m p o ral muscle is four times heavier than it is in females (197).

In patients w h o at the beginning of the experiment w e r e in a state of negative nitrogen balance, the wearing-off of the effect w a s delayed and the rebound p h e n o m e n o n often w a s completely a b s e n t (see Fig. 15). T h e m o s t important general relationships b e t w e e n androgens or anabolic steroids and the metabolism of protein shall be summarized briefly. 54 IV. ACTIVITIES — _ rv> — — (\) Anabolic agent — Daily nitrogen excretion (gm) in the urine Daily nitrogen excretion (gm) in the urine 1.

N , Ca every 1 8 - 2 4 days retention (323) (322) (307) (310) (142) 52 IV. ) 19-norandrost-4-en-3-one 50 mg 50 mg (oral) 5 0 mg (oral) 50 mg (oral) 17a-Ethyl-19-norandrost4-en-17/3-ol 5 mg (oral) 5 mg (oral) N , P, K retention N , P, K retention N , P, K, Ca retention N retention N retention N , Ca retention N , P, Ca retention Reference (314) (315) (319) (320) (321) (787) (788) "To retain clarity in this table, w e have refrained from indicating the particular diseases of the experimental subjects.

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