By Wojciech Gorczyca
This wide reference overlaying neoplastic hematopathology comprises over 500 color illustrations depicting hematopoietic tumors related to lymph nodes, spleen, bone marrow, and usually affected extranodal organs, with certain emphasis at the differential analysis. It discusses simple scientific, prognostic, morphologic and phenotypic info, with various tables summarizing the phenotypic profiles of the most typical hematologic tumors. an important characteristic of this e-book is an method of hematologic tumors according to the WHO class, with correct examples and emphasis at the most precious morphologic and immunophenotypic good points utilized in diagnosis.It could be a useful reference for all working towards hematologists, oncologists and pathologists.
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17 compares expression of pan-T antigens in benign lymph node (upper panels) and peripheral T-cell lymphoma (lower panels). Note increase in forward scatter and loss of CD5 and CD7 in T-cell lymphoma (residual benign T-cells are marked with *). 6 shows the frequency of loss or diminished expression of pan-T antigens in different types of peripheral T-cell lymphoproliferations. Normal expression of all four pan-T antigens does not exclude T-cell lymphoma. Typical (moderate-bright) expression of all four antigens is present in 32% of peripheral (mature) T-cell lymphomas, most commonly in T-prolymphocytic leukemia (T-PLL; 57%), followed by AILD (25%), Sezary’s syndrome (12%), anaplastic large cell lymphoma (11%), T-LGL (8%), and peripheral T-cell lymphoma, unspecified (7%).
Aberrant expression of CD5 by B-cells is typical for B-CLL/SLL and mantle cell lymphoma. 11F illustrates moderate expression of CD10 by CD19+ B-cells (upper right quadrant). 12 presents the difference between polytypic and monoclonal expression of surface light-chain immunoglobulins. 12A) shows two distinct populations of cells, based on the expression of CD20 (B and C; x-axis): CD20+ cells (B-cells) and CD20- cells (T-cells). B-cells show kappa expression (B; upper right quadrant) and lambda expression (C; upper right quadrant); therefore, they are polytypic.
18 T-PLL (A, bone marrow staining for CD3; B, molecular test Atlas of differential diagnosis in neoplastic hematopathology 34 with clonal peak (arrow); C–G, flow cytometry). Flow cytometry immunophenotyping shows no loss of pan-T antigen expression (D–G). Lack of aberrant expression of pan-T antigens does no exclude malignancy. g. CD33 or CD117. 9 presents a comparison between the mature and precursor T-cell neoplasms. TALL/LBL more often shows dimmer expression of CD45, lack of CD2 and CD3 (surface), dual positive or dual negative CD4/CD8 expression, lack of TCR, and expression of CD10 and CD117 when compared to mature tumors20,22.