By James R. Berenson
Specialist physicians and medical researchers summarize and clarify the entire fresh advances within the biology and remedy of bone marrow-based malignancy. at the organic facet, the authors convey the features of the malignant cellphone and describe the numerous roles performed via oncogenic alterations, chromosomal anomalies, Kaposi's sarcoma herpes virus, and cytokines. New epidemiological findings and prognostic components also are analyzed. at the scientific part, the authors offer a finished assessment of traditional remedy regimens, in addition to a dialogue of more recent experimental methods regarding immunologic concentrating on, inhibitors of drug resistance, and antitumor brokers.
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Additional resources for Biology and Management of Multiple Myeloma (Current Clinical Oncology)
More detailed molecular analyses designed to identify correlations between chemical levels in body tissues with the direct assessment of DNA damage will be helpful (9,45). Carefully studied cases of high-level benzene or petroleum product exposure in individuals who developed MM have been informative. For example, in a case involving a patient who developed a plasmacytoma in the jaw (followed by widespread myeloma), this occurred at the site of chronic exposure to a petrochemical-containing dental adhesive since childhood.
Cancer Epidemiology, Biomarkers & Prevention 1999; 8:139–146. 34 Durie 67. Roberts S, Spreadborough A, Bulman B, Barber J, Evans D, Scott D. Heritability of cellular radiosensitivity: a marker of low-penetrance predisposition genes in breast cancer? Am J Hum Genet 1999; 65:784–794. 68. I dos Santos Silva, ed. Cancer epidemiology: principles and methods. International Agency for Research on Cancer, World Health Organization; 1999; Lyon, France, Oxford University Press. 69. Miller BA, Bolonel LN, Bernstein L, et al, eds.
Cancer mortality based on the recently revised doses (DS86). Radiat Res 1990; 121:120–141. 11. Rabbitt-Roff S. Incidence of multiple myeloma in UK veterans exposed to atomic radiation in Pacific Nuclear tests. Occup and Environ Med 2003; 60:e18–e36. 12. go~safety/myelomaindex/ htm. Posted 02/05/98. 13. Gilbert ES, Fry SA, Wigs LD, Voelz GL, Cragle DL, Petersen GR. Analyses of combined mortality data on workers at the Hanford site, Oak Ridge National Laboratory, and Rocky Flats Nuclear Weapons Plant.