By PD Dr. med. Ulrich F. Gruber (auth.)
The manifold difficulties of concern are nonetheless of significant significance, diagnostic and healing adventure of the "severely ailing" being provided with new info virtually each month. within the five periodicals that have came upon their solution to my table prior to now few days there are not any under 10 fascinating articles on questions relating surprise study [see Bibliography forty-one b, fifty three a, 60 a, 192 a, 242 a, 350 b, 810 a, 941 a, 1069 a, 1082 a]. the main pressing element nonetheless is to keep up as entire as attainable the target catalog of some of the surprise manifestations present in guy and in animals - but even as to view interpretations of those phenomena of their relative and temporal "truth". difficulties of concern learn aren't merely fascinating for his or her medical worth but additionally for his or her medical implication. specifically, nearly each working towards medical professional is dealing with difficulties of blood substitute very common ly. The potent or circulating blood quantity is still a major theoret ical and healing challenge within the surprise box. For years, U. F. GRUBER has pursued this question clinically and experimentally. This quantity offers with the area literature in an incredibly thorough demeanour. This booklet is made greater than a compilation by means of together with an extended record of unique paintings performed with F. D. MOORE in Boston, within the Surgical division in Chur, with 1. E. GELIN and S. E.
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Extra info for Blood Replacement
2% [1157, 1458]. 92% after blood transfusions. According to a more recent compilation , a total of 430 transfusion reactions (including hemolytic complications) occured in 28,273 whole blood transfusions, i. e. 52%. 28 Various Methods of Volume Replacement 7. Citrate Toxicity Preserved blood contains 100-120 ml ACD solution (solutio anticoagulans). 9 mMol glucose (Ph. H. ). The addition of larger amounts of sodium citrate at first causes a metabolic acidosis, especially if the citrate cannot be broken down immediately in the liver, as for example in severe shock, serious liver disease, and in infants.
Reduction of Bacterial Resistance ALLGOWER [32, 33, 34] has shown in vitro that transfusion of citrated blood clearly reduces the phagocytic capability of neutrophile leucocytes for bactetia. OLLODART  assumes on the basis of his investigations that the treatment of blood losses with stored homologous citrated blood does not restore the RES function already reduced by shock, and instead makes it worse. These findings perhaps explain in part the many serious infections which are seen after management of severe blood losses.
G. ALLEN et al. J. G. ALLEN and W. A. J. G. ALLEN SAYMAN W. BEHRENDS and N. STEINHARDT S. N. COHEN and W. J. DOUGHERTY S. CRONBERG et al. E. A. FRIEDMAN and G. E. THOMSON G. F. GRADY et al. A. HASSIG et al. H. HEISTO G. C. HILL P. I. HOXWORTH et al. R. KATZ et al. J. J. KREBS and P. SCHARENBERG C. M. KUNIN S. MAURER G. S. MIRICK et al. L. ODIN J. PROCHAZKA O. RAMGREN and J. E. TENGBERG H. REISSIGL K. W. SCHNEIDER A. W. SCHWENZER J. R. SENIOR N. SHIMADA et al. Year Reference 1959 1962 1966,1966 1961 1963 1963 1966 1964 1953,1955, 1963,1966 1958 1965 1959 1957 1959 1959 1954 1965 1965 1966 1954 1957 1960 1956 1965 1954 1965 1965   [28,29]      [662,664, 669,675]                   a) The Frequency of Transfusion Hepatitis Icteric Form.