Blood Safety and Surveillance by Jeanne Linden

By Jeanne Linden

Manhattan country division of wellbeing and fitness, Albany. present and authoritative reference at the hazards and risk-preventing concepts of blood transfusions. Compiles facts at the reactions, immunological problems, and capability for disorder transmission regarding blood transfusions in a huge context.

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Despite these risk factors, all such donated units tested HIV seronegative. On follow-up investigation, however, it was found that two donors subsequently seroconverted for HIV. These data suggest that telephone callback may have had a beneficial effect on eliminating infectious HIV window period units; however, because of the small number of observations, it is not possible to evaluate the extent of this impact. Blood centers must have established policies for managing postdonation telephone callback information.

These can be more concisely summarized into two broad considerations: halting secondary spread of infection and the potential for intervening, or at least monitoring, the natural history of the disease. Testing of donated blood for anti-HIV, anti-HTLV, and anti-HCV has given rise to the identification of blood donors who are HIV, HTLV, or HCV infected and who have given previous, transfusable donations prior to the implementation Blood Donor Screening and Transfusion Safety 35 of blood screening.

Data for nonsexual household transmission of HCV are more equivocal, and it is unclear whether nonsexual contacts of such patients pose a risk to recipients (98). Nevertheless, FDA requires that such prospective donors must be deferred. On the other hand, persons who occasionally eat a meal or visit a patient who has viral hepatitis may have little hepatitis risk; medical judgment should be utilized to determine whether a particular donor with this type of history should be deferred. FDA requirements do not formally apply to sexual or close contacts of asymptomatic or symptomatic chronic carriers of HBV and HCV.

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