Blood Smears Reinterpreted by Marcel Bessis

By Marcel Bessis

The translation of Blood Smears Reinterpreted was once all started while the French unique was once nonetheless present process revisions. i used to be accorded the oppor­ tunity to query any assertion or flip of word that was once uncertain to me or seemed susceptible to misinterpretation. it's my wish that for this reason, ambiguities-particularly these inherent in changes among American and european ropean usage-have been got rid of and i have not less than ap­ proached the last word objective of any translation: to mirror the author's goal appropriately whereas last as readable because the unique. past the position of translator, i used to be inspired to imagine the function of critic. therefore, a few pages or maybe unmarried sentences have been hotly debated, occasionally for hours, as Marcel Bessis insisted that any inter­ pretations on which shall we now not agree will be so indicated. in truth our dialogue continually resulted in contract, although they ended in alterations of a sentence the following or a notice there and, infrequently, to the addition of a footnote or a quick paragraph.

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Simultaneous changes of the cell membrane and within the red cells are responsible for progressive deterioration of cellular functions which make the red cell more and more susceptible to hemolysis and adherence to histiocytes which eventually phagocytize them. A large number of isotopic investigations have attempted to identify the exact locus of red cell destruction. They have shown that the liver and the spleen playa predominent role in the process. These investigations were undertaken under experimental conditions which do not reflect the normal physiologic processes.

To what extent these cells mayor may not resemble the candidate stem cells of the bone marrow is still controversial. The stem cells of the Circulating blood must not be confused with transformed lymphocytes, which can also be found in the peripheral blood as a result of antigenic stimulation (see p. 154). 25% of white blood cells. Fixed Stem Cells of the Hemopoietic Tissues Ultimately, the spherical free stem cells must be derived from earlier fixed cells, at least in the embryo. In the past, the reticulum cells of the bone marrow have been thought of as the original stem cells.

Examination with phase contrast microscopy together With time lapse cinematography has allowed us to study in detail the entire processes of agony, death and necrosis. The appearances reflecting agony, death and necrosis depend on several factors: the cause of death, the type of cell, the environment and the speed with which the sequence of agony, death and necrosis develops. Phase Contrast Microscopy' 22 1) Period of agony. This period begins when alterations of the cellular organelles become irreversible.

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