By Richard K. Burt
The original, compact, pocket-sized structure of Bone Marrow Transplantation makes this article a pragmatic. ready-reference for apartment officials, fellows, nurses and pharmacists at the bone marrow transplant unit. issues coated comprise: ailments requiring bone marrow transplants, reminiscent of a number of myeloma, lymphomas, pediatric malignancies and grownup good tumors; symptoms, issues, drug doses and ways to medical administration difficulties; unrelated donors, marrow processing, engraftment relapse and basic sufferer care; and the necessities for protecting a bone marrow transplant unit.
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II) WELCH STUDY The first study of bone marrow transplantation for a hematologic malignancy, acute nonlymphocytic leukemia, was conducted by Welch et al in 1989. This study evaluated 41 patients who participated in a prospective trial of allogeneic bone marrow transplantation versus intensive chemotherapy. All of the patients had induction chemotherapy at the Fred Hutchinson Cancer Center in Seattle with all transplants supervised by the same team of doctors. Seventeen patients had an HLA matched donor and therefore received an allogeneic bone marrow transplant, while 19 patients did not have a suitable donor and received two courses of consolidation chemotherapy followed by monthly maintenance chemotherapy.
Both cellulitis and osteomyelitis can occur and septicemia has also been reported. The most common pathogens are gram positive organisms and treatment strategies in the event of infection should take this into account. 7) Embolism Pulmonary embolus has been reported after bone marrow harvest, but is a rare complication. IV) BONE MARROW RE-INFUSION A) INDICATIONS Patients who have received radiation and/or chemotherapy in doses lethal to the bone marrow in an attempt to treat their hematologic malignancies or solid tumors.
4. 4. 4. 00 = conditioning agents cost based on 70 kg patient SUGGESTED READING 1. Welch GH, Arson BE. Cost effectiveness of bone marrow transplantation in acute nonlymphocytic leukemia. N Eng J Med 1989; 32(12):807-812. 2. Bennett CL, Armitage JL, Armitage GO et al. Costs of care and outcomes for high-dose therapy and autologous transplantation for lymphoid malignancies: results from the University of Nebraska 1987 through 1991. JCO 1995; 13(4):969-973. 3. Finkler SA. The distinction between cost and charges.