The preeminent ebook on melanoma cytogenetics—now in a important new edition
Like its profitable predecessors, Cancer Cytogenetics, 3rd variation maintains to provide authoritative insurance of neoplastic methods on the chromosomal point of genomic association. Now up to date and extended, this new version contains distinctive details at the latest advances within the box, incorporating an unlimited volume of recent cytogenetic in addition to molecular genetic facts from the most recent simple and scientific investigations.
Edited via major gurus, who're now aided through a panel of internationalexperts, this new version has been up-to-date to incorporate:
- Greatly multiplied assurance of sturdy tumors
greater insurance of acute and persistent myeloproliferative problems
the newest findings on acute and persistent lymphoproliferative issues
Cancer Cytogenetics, 3rd variation is a precious source for researchers in a variety of fields, together with cytogenetics, scientific and molecular genetics, mobile and molecular biology, oncology, and hematology. With its entire insurance of thecytogenetic mechanisms underlying neoplasia, and continuously with a willing eye at the scientific outcomes of a number of the received genetic aberrations, this article will alsobe an imperative reference for all clinicians fascinated by the prognosis and remedy of melanoma patients.Content:
Chapter 1 a brand new method of an outdated challenge (pages 1–7): Sverre Heim and Felix Mitelman
Chapter 2 Cytogenetic equipment (pages 9–16): David Gisselsson
Chapter three Cytogenetic Nomenclature (pages 17–23): Sverre Heim and Felix Mitelman
Chapter four Nonrandom Chromosome Abnormalities in Cancer—An assessment (pages 25–43): Sverre Helm and Felix Mitelman
Chapter five Acute Myeloid Leukemia (pages 45–139): Bertil Johansson and Christine J. Harrison
Chapter 6 Myelodysplastic Syndromes (pages 141–178):
Chapter 7 persistent Myeloid Leukemia (pages 179–207): Thoas Fioretos and Bertil Johansson
Chapter eight persistent Myeloproliferative Neoplasms (pages 209–232): Peter Vandenberghe, Lucienne Michaux and Anne Hagemeijer
Chapter nine Acute Lymphoblastic Leukemia (pages 233–296): Christine J. Harrison and Bertil Johansson
Chapter 10 Mature B? and T?cell Neoplasms and Hodgkin Lymphoma (pages 297–374): Reiner Siebert
Chapter eleven Tumors of the higher Aerodigestive Tract (pages 375–413): Mihaela Avramut and Susanne M. Gollin
Chapter 12 Tumors of the Lung (pages 415–428): Penny Nymark, Eeva Kettunen and Sakari Knuutila
Chapter thirteen Tumors of the Digestive Tract (pages 429–461): Georgia Bardi and Sverre Helm
Chapter 14 Tumors of the Urinary Tract (pages 463–491): Paola Dal Cin and Azra H. Ligon
Chapter 15 Tumors of the Breast (pages 493–516): Manuel R. Teixeira, Nikos Pandis and Sverre Heim
Chapter sixteen Tumors of the feminine Genital Organs (pages 519–556): Francesca Micci and Sverre Heim
Chapter 17 Tumors of the Male Genital Organs (pages 557–575): Manuel R. Teixeira and Sverre Heim
Chapter 18 Tumors of Endocrine Glands (pages 577–596): Jorn Bullerdiek and David Gisselsson
Chapter 19 Tumors of the apprehensive method (pages 597–619): Aaron M. Bender, Fausto J. Rodriguez, Gobinda Sarkar and Robert B. Jenkins
Chapter 20 Tumors of the attention (pages 621–639): Karen Sisley
Chapter 21 Tumors of the outside (pages 641–653): Fredrik Mertens and Sverre Heim
Chapter 22 Tumors of Bone (pages 655–674): Fredrik Mertens and Nils Mandahl
Chapter 23 tender Tissue Tumors (pages 675–711): Nils Mandahl and Fredrik Mertens
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Additional info for Cancer Cytogenetics, THIRD EDITION
We emphasize that this evolutionary scenario is not principally dependenton whetherthe neoplasticprocess startsout as monoclonal(as implied above) or begins with the more or less simultaneoustransformationof many cells. , 1988; Heim, 1993). , 1996) in that primaryaberrations consist of specific gene rearrangements, whereassecondarychromosomalchangesresult in large-scale genomic imbalances. According to this hypothesis, then, there are no unbalancedprimaryaberrations,only secondary imbalancesmasqueradingas primary.
Hum Mol Genet 16Spec No I R88495. Adv Cancer Res 90~91-125. Curr Opin Cell Biol 18:307-3 16. DNA Repair 3: 1207- 1217. Adv Cancer Res 91 :1-30. Nature 45 I :335-339. EscobarPA, SmithMT, VasishtaA, HubbardAE,ZhangL (2007): Leukaemia-specific chromosome damagedetected by comet with fluorescence in situ hybridization(comet-FISH). Mulagenesis 22:321-327. Mutat Res 592:18-28. Oncogene 2:431435. Gisselsson D (2005): Mitotic instability in cancer: is there method in the madness? Cell Cycle 4:1007- 1010.
WHY AND HOW DO CHROMOSOME ABERRATIONS ARISE? Are primaryand secondarychromosomeabnormalitiesalwaystheresultof chanceevents? This is a thoroughlylogical, simple, and attractivepossibility,and it is probably the hypothesis shared by the majorityof researchersin the field. However, a different scenariocannot be ruled out: certaingenomic rearrangements, perhapsespecially those which frequentlyoccur as primaryabnormalities,might be preferentiallyinduced, for example,throughdirectinteractionbetweena carcinogenicagentandspecificgenomicsites in the target cells.