Chicken Pox (Deadly Diseases and Epidemics) by Patrick Guilfoile

By Patrick Guilfoile

Poultry pox used to be a ceremony of passage for kids and was once usually appeared upon as only a nuisance, even supposing this sickness may cause issues in a few humans. This name provides an summary of this disorder as a result of a herpes virus often called the varicella-zoster virus, explaining the symptoms of the illness.

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Extra resources for Chicken Pox (Deadly Diseases and Epidemics)

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Based on research using SCID mice containing human skin and immune cells, researchers have discovered that the varicella-zoster virus infects a type of human immune cell called memory T-cells. S. 10 Another important model of chicken pox involves the use of SCID mice. Because of a mutation in a gene required for normal development of cells of the immune system, these mice lack immune responses. Consequently, it is possible to graft human tissue to or to inject human cells into these mice and they do not reject the transplants.

Indd 56 8/5/09 9:21:48 AM How Is Chicken Pox Diagnosed and Treated? 1 A biologist prepares a polymerase chain reaction (PCR) assay, a test that allows researchers to identify viruses by detection of viral DNA. S. Department of Health and Human Services) The DNA polymerase uses the primers as starting points for DNA synthesis. The key to this method is the use of primers that uniquely recognize the varicella-zoster virus DNA, and not the DNA from any other virus or other pathogen. The use of proper primers makes this test highly specific for chicken pox.

After new viruses are produced they leave the host cell—sometimes destroying the host cell—and proceed to infect other cells. indd 34 8/5/09 9:21:41 AM Chicken Pox in Young Children 35 and begins replicating. Initially, the virus replicates slowly in the skin cells. This is thought to be in part because of the chemicals the skin cells naturally produce (antiviral molecules like interferon alpha). As the virus infects skin cells, it prevents infected cells from making those antiviral chemicals. Eventually, enough cells are infected, and enough viruses are produced, that skin damage becomes evident in the form of lesions and a rash.

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