By William Coleman
Cholera is likely one of the oldest identified and best-understood infectious illnesses. Thriving in unclean water, it is still a favourite killer in nations the place sanitary water resources are scarce. This booklet describes the background of this infectious affliction and discusses features that allow the microorganism to reason severe illnesses.
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Additional info for Cholera (Deadly Diseases and Epidemics)
New York: Plenum, 1998. 1. Cholera spread throughout Latin America in 1991. This map shows the route of disease transmission. The epidemic was thought to be the result of ballast water exchange from ships in the area, but this was never proved. the population. Most people who harbor the cholera bacillus within their body do not show sym ptoms, and are thus label ed as asymptomatic. One estimate is that just two percent of n ew cases are severe, five percent are modera te , and 18 percent have mild sym ptoms.
When the cholera toxin is present, it attaches the ADPribose from NAD to the alpha-GTP protein, preventing it from 61 06 Cholera 054-063 62 2/15/08 8:06 AM Page 62 CHOLERA recycling by release of a phosphate group. This inactivated alpha-GTP protein promotes dissociation of the G protein complex and inactivates an enzyme that can convert GTP to GDP (GTPase). The result is that cAMP formation continues, while the ability of the cell to turn off the formation of cAMP is lost. The G protein can no longer be recycled and the formation of cAMP continues.
Rows of small co ttages inhabited by poor people were separated by a single street in Horsleytown, England. The north side of the cottages was called Surrey Buildings, and the south side of the cottages was called Truscott’s Court. During 1849, there were many cases of cholera in the Surrey Buildings but only two cases in Tru s co t t’s Court. Ho u s ehold wastewater was poured into a channel in front of the houses in both cases, The wastewater from the residents of the Surrey Buildings (and not Truscott’s Court) reached the well which the residents used for drinking water.