Chronic Lymphocytic Leukemia: Molecular Genetics, Biology, by Guy B. Faguet

By Guy B. Faguet

Veterans Affairs scientific heart, Augusta, GA. reports medical advances in molecular genetics and biology of continual lymphocytic leukemia. Discusses the scientific points, concentrating on analysis, diagnosis, treatments, and issues. additionally addresses familial and juvenile circumstances. DNLM: Leukemia, Lymphocytic, continual.

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Additional resources for Chronic Lymphocytic Leukemia: Molecular Genetics, Biology, Diagnosis, and Management

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Table 2 Causes of Death in 161 Patients With Chronic Lymphocytic Leukemia Patients Cause No. (%) Infection Other disease Cachexia Anemia Hemorrhage Uncertain 101 31 22 14 5 21 (63) (19) (14) (9) (3) (13) From ref. 29, 1973, Table 5. With permission from the European Journal of Hematology. red cells (macrocytosis, anisocytosis, and sometimes spherocytosis with polychromatophilia) is particularly apt in the absence of a slight rise in the serum bilirubin and when reticulocytes are not noticeably increased.

It was felt that the large variability in this group was not well explained. The French CLL group, under the leadership of Binet, proposed in 1977, revised in 1981, and presented in 1981 a new classification based on three prognostic groups: C, B, and A (49–51). Group C was defined as anemia (Hgb < 10 g/dL) and/or thrombocytopenia (platelets < 100,000 µL); group B as no anemia, no thrombocytopenia, three or more involved areas (counting as one each of the following: cervical, axillary, inguinal lymph nodes, whether unilateral or bilateral, spleen, and liver); and group A as no anemia, no thrombocytopenia, and less than three involved areas.

36). 4. Molecular Genetics In 1987 and 1989, Shen et al. (99) and Kipps et al. (100) made a major contribution to the molecular analysis of Ig genes in CLL. Their initial observation was that the B-cell antibody repertoire in CLL was limited. This was based on the finding that certain variable (V) region heavy chain (H) Ig genes were expressed more frequently and in fact that certain genes within a given family were expressed at an even higher frequency. Further analysis by Fais et al. (101) in 1998 of the B-cell receptor (BCR) showed that it can be either mutated or unmutated.

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